The most appropriate antonym for the underlined word "blessed" in the given sentence is "cursed." "Blessed" implies being favored, protected, or endowed with divine grace, while "cursed" suggests being subjected to divine displeasure or misfortune. The other options— "appointed" (designated for a specific role), "produced" (created), and "applied" (put into action)— do not convey the opposite meaning of "blessed" in this context.

"Primitive" refers to something that is simple, basic, or undeveloped. On the other hand, "Sophisticated" implies complexity, refinement, and advanced development. Therefore, option (C) Sophisticated is the opposite or antonym of "Primitive."

"Difference" implies a degree of dissimilarity or distinction, and "Similarity" represents the opposite, indicating things that are alike or have common features. Therefore, option (A) Similarity is the most suitable antonym in this context.

"Conceit" refers to an excessive sense of self-importance or pride, often accompanied by an overestimation of one's abilities. The antonym, "Modesty," represents a quality of being humble, unassuming, and free from excessive pride or self-assertion. Therefore, option (C) Modesty is the opposite or antonym of "Conceit."