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Q: Which of the following statements is most accurate regarding infection with parvovirus B19?

  • 1
    Parvovirus B19 causes severe anemia because it preferentially infects erythrocyte precursors
  • 2
    Parvovirus B19 can cause hydrops fetalis via transplacental infection of a fetus in a seropositive mother
  • 3
    Parvovirus B19 can be diagnosed by detection of viral RNA using PCR or hybridization assays
  • 4
    Parvovirus B19 replicates in the host cell nucleus utilizing a virally encoded DNA polymerase to create a double- stranded DNA intermediate
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Answer : 1. "Parvovirus B19 causes severe anemia because it preferentially infects erythrocyte precursors"
Explanation :

Answer: A) Parvovirus B19 causes severe anemia because it preferentially infects erythrocyte precursors Explanation: Parvovirus B19 causes severe anemia because it preferentially infects erythrocyte precursors.   a. Parvovirus B19 binds preferentially to the erythrocyte blood group P antigen on erythroid precursor cells. Answers B, C, D are incorrect: b. after entry the single-stranded viral DNA genome is transported to the cell nucleus where the host DNA polymerase synthesizes the complimentary DNA strand. c. Parvovirus B19 infection can be diagnosed by direct detection of viral DNA not RNA. d. the fetus of a seropositive mother is protected from infection by maternal circulating antibodies.

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